40folds
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About us

Helping leadership teams make better commercial decisions, with confidence.

40folds builds digital twins of a company’s commercial engine. We bring methods proven over two decades in biomedical research to the boardroom, so that finance, marketing and sales can agree on what drives the business — and where to invest next.

Founded
2025
Paris, France
Incubated at
Station F
INSEAD Launchpad programme
Backed by
Acurio Ventures
Pre-seed investor
Our mission

Give every executive committee one trusted view of what drives growth.

Today, the most consequential investment questions — why results are above or below plan, what a launch really delivered, how to reallocate budgets — are answered by department-owned analyses that rarely agree. We replace them with one consistent, independently validated model of the business, whose uncertainty is explicit and whose recommendations a CFO can defend.

Our vision

Digital twins, trusted in medicine and aerospace, as standard practice in business.

Mission-critical industries do not take decisions on a single, unvalidated model. We believe commercial decisions deserve the same discipline: a living representation of the business, governed by its own economic laws, refreshed continuously and used by leadership to plan, test and allocate resources.

Leadership

Experience from consulting, industry and science.

Rares Rusu, MBA

Rares Rusu, MBA

Co-founder & Chief Executive Officer

Twenty years in C-level strategy and budget-allocation discussions. Four years at McKinsey & Company, then fourteen years at Google — as Marketing Director for Central and Eastern Europe and CFO for Southern Europe. Author of a Google white paper on measuring marketing ROI in net-profit terms. INSEAD MBA.

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Matías Bossa, PhD

Matías Bossa, PhD

Chief Scientist

PhD in Biomedical Engineering and twenty years of Bayesian statistics, with more than 1,000 citations. Developed disease-progression models and clinical digital twins whose methods now underpin the 40folds optimisation engine.

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Andrei Popescu, PhD

Andrei Popescu, PhD

Applied Scientist

PhD-trained applied scientist specialising in machine learning, hybrid modelling and digital twins. Turns research-grade models into robust, production-ready systems for our clients.

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Bianca Rusu

Bianca Rusu

Co-founder & Chief Operating Officer

Economist and former financial analyst, and 2x co-founder with ten years building and running operations-intensive businesses. Leads administration, finance, people and compliance at 40folds.

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How we work

Rigour

Every number we present carries its uncertainty. We would rather show a range we can defend than a point we cannot.

Independence

We are not paid by media owners or agencies. Our only interest is the accuracy of the answer and the growth of our clients.

Partnership

We work alongside finance, marketing and sales leaders, so decisions are owned by the executive team — not delegated to a model.

Let’s discuss the decisions ahead of your leadership team.